# Strategy Market - Single State **URL:** https://forum.eternagame.org/c/strategy-market/strategy-market-single-state/8.md [Latest](https://forum.eternagame.org/latest.md) · [Categories](https://forum.eternagame.org/categories.md) · [Tags](https://forum.eternagame.org/tags.md) --- ## [About the Strategy Market - Single State category](https://forum.eternagame.org/t/about-the-strategy-market-single-state-category/278)
**Author:** [@LFP6](https://forum.eternagame.org/u/LFP6)\ **Replies:** 0\ **Last updated:** [June 26, 2020, 5:35pm UTC](https://forum.eternagame.org/t/about-the-strategy-market-single-state-category/278 "2020-06-26T17:35:25Z")
This area of the strategy market is for strategies relevant specifically for single state puzzles --- ## [\[Strategy market\] Blue line](https://forum.eternagame.org/t/strategy-market-blue-line/2601)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 5\ **Last updated:** [February 18, 2016, 3:08am UTC](https://forum.eternagame.org/t/strategy-market-blue-line/2601 "2016-02-18T03:08:00Z")
I like to ad a strategy that says, no strands with 3, 4 or more blue nucleotides in line. Penalize for each extra with -1. --- ## [\[Strategy market\] Catalog of necks](https://forum.eternagame.org/t/strategy-market-catalog-of-necks/2586)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 7\ **Last updated:** [January 21, 2016, 11:07pm UTC](https://forum.eternagame.org/t/strategy-market-catalog-of-necks/2586 "2016-01-21T23:07:00Z")
I woke up two days ago with a crazy idea for a strategy. Here it comes: The neckarea is regulary a pain in the neck. I would like a strategy, that re-use necks that is known to work and be highly succesfull. Sort of a c… --- ## [\[Strategy Market\] GU's in barcode](https://forum.eternagame.org/t/strategy-market-gus-in-barcode/2188)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 5\ **Last updated:** [September 24, 2014, 7:04pm UTC](https://forum.eternagame.org/t/strategy-market-gus-in-barcode/2188 "2014-09-24T19:04:00Z")
I noticed that designs with long stems that had a GU in the barcode often looked stabler than their counterparts without it. I will like this strategy: In designs with with one or more stems of the length 8-9+ basepairs… --- ## [\[Market Strategy\] GU Flip Strategy](https://forum.eternagame.org/t/market-strategy-gu-flip-strategy/2087)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 0\ **Last updated:** [March 26, 2014, 12:11am UTC](https://forum.eternagame.org/t/market-strategy-gu-flip-strategy/2087 "2014-03-26T00:11:00Z")
Read about background idea \[here\](https://getsatisfaction.com/eternagame/topics /gu\_motif#reply\_14053794). --- ## [\[Market Strategy\] GU and AU orientation](https://forum.eternagame.org/t/market-strategy-gu-and-au-orientation/2085)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 0\ **Last updated:** [March 25, 2014, 11:54pm UTC](https://forum.eternagame.org/t/market-strategy-gu-and-au-orientation/2085 "2014-03-25T23:54:00Z")
I would like a strategy that says: 2 if purine (R) (Guanine and Adenine) is to the right 1 if pyrimidine (Y) (Cytosine and Uracil) is to the right Idea background here. This is for multiloops, in case the closing bas… --- ## [\[Strategy market\] Tetraloop similarity](https://forum.eternagame.org/t/strategy-market-tetraloop-similarity/2082)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 8\ **Last updated:** [March 18, 2014, 6:14pm UTC](https://forum.eternagame.org/t/strategy-market-tetraloop-similarity/2082 "2014-03-18T18:14:00Z")
I would like a strategy that ad points for having similar energy content in tetraloops (like quardruplet) as best, double twin tetraloops as next best. For designs with 4 tetraloops: If all tetraloops are similar in en… --- ## [\[Strategy market\] Bad hook](https://forum.eternagame.org/t/strategy-market-bad-hook/2074)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 0\ **Last updated:** [March 12, 2014, 7:41pm UTC](https://forum.eternagame.org/t/strategy-market-bad-hook/2074 "2014-03-12T19:41:00Z")
The closer a red base is to the 2 GG’s (base 1 and 2), the worse. I think that having other colored bases than yellow on 5’ tail part, closer to the starting GG’s is worse than if they are more distanced. I have regularl… --- ## [\[Strategy market\] No blue nucleotides in hook area](https://forum.eternagame.org/t/strategy-market-no-blue-nucleotides-in-hook-area/2073)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 7\ **Last updated:** [March 12, 2014, 7:33pm UTC](https://forum.eternagame.org/t/strategy-market-no-blue-nucleotides-in-hook-area/2073 "2014-03-12T19:33:00Z")
I would like to ad a strategy, that says: No blue nucleotides are allowed in the hook area (the nucleotides beside the junctions) Give -2 for each blue nucleotide in this position --- ## [\[Strategy Market\] Use a double G on a single-basepair bulge](https://forum.eternagame.org/t/strategy-market-use-a-double-g-on-a-single-basepair-bulge/2064)
**Author:** [@salish99](https://forum.eternagame.org/u/salish99)\ **Replies:** 7\ **Last updated:** [March 6, 2014, 5:09pm UTC](https://forum.eternagame.org/t/strategy-market-use-a-double-g-on-a-single-basepair-bulge/2064 "2014-03-06T17:09:00Z")
Of the 24 possibilities of base pairs in a single base pair bulge, the G-G combination results in a -0.4J free energy, the lowest of the choices, acting with a significant attractive force without actually bonding. So, … --- ## [\[Strategy Market\] Add a red to each ring](https://forum.eternagame.org/t/strategy-market-add-a-red-to-each-ring/2052)
**Author:** [@salish99](https://forum.eternagame.org/u/salish99)\ **Replies:** 0\ **Last updated:** [February 15, 2014, 9:05pm UTC](https://forum.eternagame.org/t/strategy-market-add-a-red-to-each-ring/2052 "2014-02-15T21:05:00Z")
I suggest after adding a +1 when adding one red (G) to each ring and bulge (note that I don’t suggest a +1 for each added G, just on the overall structure), at the attachment of each hairpin - if there is a choice. One… --- ## [\[Market Strategy\] GU motif](https://forum.eternagame.org/t/market-strategy-gu-motif/2045)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 0\ **Last updated:** [February 7, 2014, 2:11pm UTC](https://forum.eternagame.org/t/market-strategy-gu-motif/2045 "2014-02-07T14:11:00Z")
General Give -2 if motif is 2 basepair or closer to closing basepair. Give -1 if motif starts in closing basepair Give + 2 for motif in stems in stems 7 bp and longer. Give + 1 if open base is complementary to moti… --- ## [\[ Strategy Market \] Stem Structure](https://forum.eternagame.org/t/strategy-market-stem-structure/2044)
**Author:** [@Valareos](https://forum.eternagame.org/u/Valareos)\ **Replies:** 1\ **Last updated:** [February 6, 2014, 8:26pm UTC](https://forum.eternagame.org/t/strategy-market-stem-structure/2044 "2014-02-06T20:26:00Z")
Hope you still receiving submissions for this. used this strategy for building in puzzles and have had a LOT of luck in solving them with this method, so Im curious how it stacks up. Bond Pairs at end of Stems: GC or CG … --- ## [\[Strategy market\] Numbers of yellow nucleotides pr. length of string](https://forum.eternagame.org/t/strategy-market-numbers-of-yellow-nucleotides-pr-length-of-string/2019)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 3\ **Last updated:** [January 10, 2014, 6:17pm UTC](https://forum.eternagame.org/t/strategy-market-numbers-of-yellow-nucleotides-pr-length-of-string/2019 "2014-01-10T18:17:00Z")
I would like to ad a strategy for numbers of yellow nucleotides allowed pr. lengt of string (neckarea excluded): If a string/arm is this number of nucleotides long, then allow this number of yellow adenine. For each yel… --- ## [\[Strategy Market\] Stacks should be made of 10% of GU pairs](https://forum.eternagame.org/t/strategy-market-stacks-should-be-made-of-10-of-gu-pairs/2017)
**Author:** [@sombra0666](https://forum.eternagame.org/u/sombra0666)\ **Replies:** 0\ **Last updated:** [January 4, 2014, 3:06am UTC](https://forum.eternagame.org/t/strategy-market-stacks-should-be-made-of-10-of-gu-pairs/2017 "2014-01-04T03:06:00Z")
(sorry for my english, i’m not from USA) Making too much of GC or AU pairs is never good, right? So i thought that maybe there should be a minimum value for the weak pairs, and that minimum quantity could, somehow, make … --- ## [\[Strategy Market\] Eternacac'c Berex Revisited](https://forum.eternagame.org/t/strategy-market-eternacacc-berex-revisited/2006)
**Author:** [@eternacac](https://forum.eternagame.org/u/eternacac)\ **Replies:** 1\ **Last updated:** [December 21, 2013, 7:12am UTC](https://forum.eternagame.org/t/strategy-market-eternacacc-berex-revisited/2006 "2013-12-21T07:12:00Z")
Gross Berex Ratio = GBR = (Non\_AU)/AU = (ideal)55/45 & both numerator & denominator are fib or sums of fib numbers. 1,1,2,3,5,8,13,21,44,65…Total Nt’s = sum of four fib numbers,i.e., 100=(21+21+13+(44+1)) each nt-group… --- ## [\[Market strategy\] Direction of GC-pairs in small and big multiloops (symmetric)](https://forum.eternagame.org/t/market-strategy-direction-of-gc-pairs-in-small-and-big-multiloops-symmetric/2005)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 2\ **Last updated:** [December 19, 2013, 1:58pm UTC](https://forum.eternagame.org/t/market-strategy-direction-of-gc-pairs-in-small-and-big-multiloops-symmetric/2005 "2013-12-19T13:58:00Z")
I would like to ad a strategy about size of multiloop Symmetic multiloop = multiloop with same numbers of nucleotides between the multiloop arms. Here is my hypothesis: Tolerance for opposite direction of GC-pairs in a… --- ## [\[Market strategy\] GU's in long stems](https://forum.eternagame.org/t/market-strategy-gus-in-long-stems/1997)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 3\ **Last updated:** [December 3, 2013, 11:46am UTC](https://forum.eternagame.org/t/market-strategy-gus-in-long-stems/1997 "2013-12-03T11:46:00Z")
Give +1 if a stem at the length of 8+ contains a GU-basepair at least 2 basepairs away from the closing basepairs. For every additional +7 basepairs a stem is long give +1 if there is another GU basepair. Background: h… --- ## [\[Strategy Market\] Stack Pair Fibonacci Ratios](https://forum.eternagame.org/t/strategy-market-stack-pair-fibonacci-ratios/1899)
**Author:** [@eternacac](https://forum.eternagame.org/u/eternacac)\ **Replies:** 0\ **Last updated:** [September 23, 2013, 4:10pm UTC](https://forum.eternagame.org/t/strategy-market-stack-pair-fibonacci-ratios/1899 "2013-09-23T16:10:00Z")
Strategy Market idea: A pairwise ratio between total stack pairs must approximate a fibonacci ratio so that any pair approaches a fib ratio with another pair. Closer to whole number fib ratio scores higher. Might order … --- ## [\[Strategy Market\] Strictly Alternating Nt's](https://forum.eternagame.org/t/strategy-market-strictly-alternating-nts/1898)
**Author:** [@eternacac](https://forum.eternagame.org/u/eternacac)\ **Replies:** 0\ **Last updated:** [September 23, 2013, 3:33pm UTC](https://forum.eternagame.org/t/strategy-market-strictly-alternating-nts/1898 "2013-09-23T15:33:00Z")
Stack nt’s of each non-A type (U,G,C) should be strictly alternating from 3’ to 5’ to 3’ etc. as you follow down the stack. Penalize each repeated violation in an exponential manner if they are in adjacent base pairs, li… --- ## [\[Market strategy\] Direction of GC-pairs in asymmetric multiloops](https://forum.eternagame.org/t/market-strategy-direction-of-gc-pairs-in-asymmetric-multiloops/865)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 3\ **Last updated:** [August 11, 2013, 12:54pm UTC](https://forum.eternagame.org/t/market-strategy-direction-of-gc-pairs-in-asymmetric-multiloops/865 "2013-08-11T12:54:00Z")
Asymmetic multiloop = multiloop with different numbers of nucleotides between the multiloop arms. I would like a strategy for designs with asymmetric multiloop. Hypothesis: the shorter between GC-pairs in multiloops, t… --- ## [\[Strategy Market\] Random Test](https://forum.eternagame.org/t/strategy-market-random-test/1828)
**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\ **Replies:** 0\ **Last updated:** [July 9, 2013, 9:47pm UTC](https://forum.eternagame.org/t/strategy-market-random-test/1828 "2013-07-09T21:47:00Z")
I’m curious to see if random nucleotide placement will truly come out to .000. What I’m proposing for this strategy market is to randomly paint nucleotides until a solution is met or until the bot times out. --- ## [\[Strategy marked\] Adjacent multiloops with non-adjacent stacks](https://forum.eternagame.org/t/strategy-marked-adjacent-multiloops-with-non-adjacent-stacks/1814)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 3\ **Last updated:** [June 22, 2013, 1:04pm UTC](https://forum.eternagame.org/t/strategy-marked-adjacent-multiloops-with-non-adjacent-stacks/1814 "2013-06-22T13:04:00Z")
I think I see a tendency for multiloops with a mixture of adjacent and non-adjacent stems. While the closing basepairs for the adjacent stem can follow usual orientation or have red facing each other and green too, the c… --- ## [\[Market strategy\] Energetic pressured designs](https://forum.eternagame.org/t/market-strategy-energetic-pressured-designs/1384)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 16\ **Last updated:** [May 26, 2013, 11:10pm UTC](https://forum.eternagame.org/t/market-strategy-energetic-pressured-designs/1384 "2013-05-26T23:10:00Z")
With this strategy I’m trying to give our robot a possibility to determine if a design is energeticly pressured. As the RNA structure is easiest kept by putting GC-pairs in the junctions, having many short strings drama… --- ## [\[Strategy market\] 2 and 3 nt bulges](https://forum.eternagame.org/t/strategy-market-2-and-3-nt-bulges/1683)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 13\ **Last updated:** [March 25, 2013, 9:06am UTC](https://forum.eternagame.org/t/strategy-market-2-and-3-nt-bulges/1683 "2013-03-25T09:06:00Z")
I have looked through The thinker lab and see following pattern for successful 2 and 3 nt bulges. The both follow same pattern. This 2 nt bulge is from Great plot and balanced melting point no GU 1 (89%) by Jennifer Pea… --- ## [\[Strategy market\] Mat's and Eli’s Perfect aptamers](https://forum.eternagame.org/t/strategy-market-mats-and-eli-s-perfect-aptamers/1647)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 3\ **Last updated:** [February 21, 2013, 10:04pm UTC](https://forum.eternagame.org/t/strategy-market-mats-and-eli-s-perfect-aptamers/1647 "2013-02-21T22:04:00Z")
I will like to ask for a strategy for static labs, that has similarities to my earlier strategy Catalog of necks. I believe that good aptamers can be recycled just as can good necks. I am asking for a big broad strategy … --- ## [\[Strategy market\] Strategy for Mat’s and Eli’s Triloop Tendency](https://forum.eternagame.org/t/strategy-market-strategy-for-mat-s-and-eli-s-triloop-tendency/1632)
**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\ **Replies:** 1\ **Last updated:** [February 8, 2013, 7:02pm UTC](https://forum.eternagame.org/t/strategy-market-strategy-for-mat-s-and-eli-s-triloop-tendency/1632 "2013-02-08T19:02:00Z")
STRATEGY PART 1 - Closing basepair For the closing basepair of a triloop I had a strategy clear in my mind. +2 if right base is a C, +1 if right base is a G. 1 if closing basepair is GC. After reading the forum pos… --- ## [Reward Low Standard Deviation of Free Energy](https://forum.eternagame.org/t/reward-low-standard-deviation-of-free-energy/1581)
**Author:** [@Ramfublio](https://forum.eternagame.org/u/Ramfublio)\ **Replies:** 3\ **Last updated:** [December 27, 2012, 2:55pm UTC](https://forum.eternagame.org/t/reward-low-standard-deviation-of-free-energy/1581 "2012-12-27T14:55:00Z")
My strategy would be to try to reward evenness in free energy. Solutions with a low standard deviation would be scored higher. Others would know the specific numbers better, but as an example, if a design were to have a… --- ## [Preventing Mismatches by Lower Energy and Consecutive A's](https://forum.eternagame.org/t/preventing-mismatches-by-lower-energy-and-consecutive-as/1460)
**Author:** [@ribonucleic](https://forum.eternagame.org/u/ribonucleic)\ **Replies:** 0\ **Last updated:** [October 21, 2012, 6:18pm UTC](https://forum.eternagame.org/t/preventing-mismatches-by-lower-energy-and-consecutive-as/1460 "2012-10-21T18:18:00Z")
Ok, just testing out Strategy market: Only 2 Adenines in a row Melting point of 77 to 97 Free energy of -18 to -32 16% U bases 20% C bases 24% G bases Thanks to everybody for your support! --- ## [\[Strategy Market\] Ideas](https://forum.eternagame.org/t/strategy-market-ideas/1448)
**Author:** [@ngmgetsat](https://forum.eternagame.org/u/ngmgetsat)\ **Replies:** 1\ **Last updated:** [October 10, 2012, 7:45pm UTC](https://forum.eternagame.org/t/strategy-market-ideas/1448 "2012-10-10T19:45:00Z")
Create G - C pairs to clamp the edge of each loop (even if the max number of G - C pairs is initially exceeded. Attempt to flip G - C pairs one by one until folding is as close to the target as possible. If folding is a… [Next page](https://forum.eternagame.org/c/strategy-market/strategy-market-single-state/8.md?page=1)