# Strategy Market - Single State

**URL:** https://forum.eternagame.org/c/strategy-market/strategy-market-single-state/8.md?page=2

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**Page:** 3

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## [\[Strategy market\] Twist of some of the GC-pairs in strings](https://forum.eternagame.org/t/strategy-market-twist-of-some-of-the-gc-pairs-in-strings/1220)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [March 24, 2012, 10:54am UTC](https://forum.eternagame.org/t/strategy-market-twist-of-some-of-the-gc-pairs-in-strings/1220 "2012-03-24T10:54:00Z")

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Sometimes there is a penalty for having all GC-pairs in a string, turn in the same direction, even if they are not right besides each other. (They will typically be places in each end of a string, in junctions.) This is…

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## [\[Strategy market\] Double AU-pair strategy](https://forum.eternagame.org/t/strategy-market-double-au-pair-strategy/1217)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [March 23, 2012, 4:30pm UTC](https://forum.eternagame.org/t/strategy-market-double-au-pair-strategy/1217 "2012-03-23T16:30:00Z")

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I would like to ad a strategy that says, there can be 0 or 1 double AU-pair in the design (two AU-pairs turning the same way.) For more than one double AU-pair, ad -1 pr. extra. Neckarea is the exception to this strateg…

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## [\[Market strategy\] Aptamer designs with red twin sequences](https://forum.eternagame.org/t/market-strategy-aptamer-designs-with-red-twin-sequences/1213)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [March 19, 2012, 4:18am UTC](https://forum.eternagame.org/t/market-strategy-aptamer-designs-with-red-twin-sequences/1213 "2012-03-19T04:18:00Z")

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I have noticed in aptamer designs, that certain sequences in the the aptamer have a habit of pairing up with certain sequences in the design. It is actually an old problem from earlier labs too, just here it was sequence…

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## [\[Market strategy\] Mat - Red paired with green](https://forum.eternagame.org/t/market-strategy-mat-red-paired-with-green/1212)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [March 19, 2012, 4:15am UTC](https://forum.eternagame.org/t/market-strategy-mat-red-paired-with-green/1212 "2012-03-19T04:15:00Z")

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This strategy is the natural sibling of the strategy Green paired with red and Blue paired with yellow. Here the strategy comes: For each red nucleotide not paired up with green (alone – placed in end loops, internal lo…

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## [\[Market strategy\] Double sameturning pairs with multiloop junction.](https://forum.eternagame.org/t/market-strategy-double-sameturning-pairs-with-multiloop-junction/1205)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [March 12, 2012, 8:22pm UTC](https://forum.eternagame.org/t/market-strategy-double-sameturning-pairs-with-multiloop-junction/1205 "2012-03-12T20:22:00Z")

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Earlier I made a strategy to minimize the use of double sameturning pairs, with max one pr symmetric design and two for asymmetric as they mostly causes trouble. I didn’t specify where they were allowed. It seems that th…

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## [\[Market strategy\] Colored hairpin lines](https://forum.eternagame.org/t/market-strategy-colored-hairpin-lines/1190)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 29, 2012, 3:43pm UTC](https://forum.eternagame.org/t/market-strategy-colored-hairpin-lines/1190 "2012-02-29T15:43:00Z")

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\[Market strategy\] Colored hairpin lines Came up with the idea for this strategy a week back, while I was on a walk. Until recently I have only made strategies, that penalizes inside an specific element. But the sequenc…

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## [\[Market strategy\] Boost or no boost depending on loopsize](https://forum.eternagame.org/t/market-strategy-boost-or-no-boost-depending-on-loopsize/1189)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 29, 2012, 3:41pm UTC](https://forum.eternagame.org/t/market-strategy-boost-or-no-boost-depending-on-loopsize/1189 "2012-02-29T15:41:00Z")

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Hairpins with tetraloops and pentaloops mostly seem to be fine without boosting. (Strings 4 nts and longer) However hairpins with loops bigger than a pentaloop, some sort of boost seems to be necessary. (Strings 4 nts an…

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## [\[Market strategy\] GC-content in adjacent multiloops (4 basepairs)](https://forum.eternagame.org/t/market-strategy-gc-content-in-adjacent-multiloops-4-basepairs/1188)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [February 29, 2012, 3:40pm UTC](https://forum.eternagame.org/t/market-strategy-gc-content-in-adjacent-multiloops-4-basepairs/1188 "2012-02-29T15:40:00Z")

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Here is a strategy for our little bot, as I can see he is not sure what to do when around adjacent multiloops. :slight\_smile: I would like a strategy for adjacent multiloops (4 basepairs) that says: At least 2 of the b…

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## [\[Market strategy\] Never two sameturning double pairs in a string of the length 4](https://forum.eternagame.org/t/market-strategy-never-two-sameturning-double-pairs-in-a-string-of-the-length-4/1187)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 29, 2012, 3:38pm UTC](https://forum.eternagame.org/t/market-strategy-never-two-sameturning-double-pairs-in-a-string-of-the-length-4/1187 "2012-02-29T15:38:00Z")

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I caught our bot in following situation three times with equally bad results. The double AU pair generally broke open and the double sameturning GC-pairs slided. I would like a strategy that says, no two pai…

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## [\[Market strategy\] Chris Cunningham's adjacent multiloops (4 basepairs)](https://forum.eternagame.org/t/market-strategy-chris-cunninghams-adjacent-multiloops-4-basepairs/1185)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [February 29, 2012, 3:37pm UTC](https://forum.eternagame.org/t/market-strategy-chris-cunninghams-adjacent-multiloops-4-basepairs/1185 "2012-02-29T15:37:00Z")

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When I was looking through the lab results for the aptamers with the adjacent multiloop (FMN Apatamer with single binding site I and FMN Aptamer with Single Binding Site II) I noticed a pattern that seem to cause the mul…

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## [\[Market strategy\] Forbidden pattern in the ends of hairpin loops](https://forum.eternagame.org/t/market-strategy-forbidden-pattern-in-the-ends-of-hairpin-loops/1184)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 29, 2012, 3:36pm UTC](https://forum.eternagame.org/t/market-strategy-forbidden-pattern-in-the-ends-of-hairpin-loops/1184 "2012-02-29T15:36:00Z")

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I have long stated that long strings are less rulesensitive. (See my post about Rulesensitivity according to length of string). But there are exceptions. I think this pattern will be bad in all lenght of strings. I will…

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## [\[Strategy Market\]a voting system that will save you time no voting just pick the top players  with the most labs done and the most points,](https://forum.eternagame.org/t/strategy-market-a-voting-system-that-will-save-you-time-no-voting-just-pick-the-top-players-with-the-most-labs-done-and-the-most-points/1164)

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**Author:** [@Joshua\_Weitzman](https://forum.eternagame.org/u/Joshua_Weitzman)\
**Replies:** 0\
**Last updated:** [February 13, 2012, 2:32pm UTC](https://forum.eternagame.org/t/strategy-market-a-voting-system-that-will-save-you-time-no-voting-just-pick-the-top-players-with-the-most-labs-done-and-the-most-points/1164 "2012-02-13T14:32:00Z")

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\[Strategy Market\]a voting system that will save you time no voting just pick the top players with the most labs done and the most points, suck the fun out and block out new peaple from contributing to the game. make an u…

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## [\[Strategy Market\] G to C Ratio](https://forum.eternagame.org/t/strategy-market-g-to-c-ratio/1160)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 4\
**Last updated:** [February 10, 2012, 7:19pm UTC](https://forum.eternagame.org/t/strategy-market-g-to-c-ratio/1160 "2012-02-10T19:19:00Z")

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If an RNA has the same number of Cytosines as Guanines, consider it be neutral. If an RNA has fewer Cytosines than guanines, reward it up to a certain point. I would say stop rewarding the structure at 25-50% fewer Cytos…

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## [\[Strategy Market\] Modified Aldo's Loops and Stacks](https://forum.eternagame.org/t/strategy-market-modified-aldos-loops-and-stacks/1158)

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**Author:** [@Quasispecies](https://forum.eternagame.org/u/Quasispecies)\
**Replies:** 0\
**Last updated:** [February 10, 2012, 3:32pm UTC](https://forum.eternagame.org/t/strategy-market-modified-aldos-loops-and-stacks/1158 "2012-02-10T15:32:00Z")

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AU pairs: +1 point in the interior of stacks +0.5 points at end of stacks GU pairs: +1 point at end of stacks, when loop is 5’ of G -1 point at end of stacks, when loop is 3’ of G -1 point when inside of stack and …

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## [\[Market strategy\] Drake's yellow nucleotide strategy](https://forum.eternagame.org/t/market-strategy-drakes-yellow-nucleotide-strategy/1147)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 0\
**Last updated:** [February 6, 2012, 11:02pm UTC](https://forum.eternagame.org/t/market-strategy-drakes-yellow-nucleotide-strategy/1147 "2012-02-06T23:02:00Z")

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Drake beat my player puzzle tripple tri-loops and solved it with 10 GU-pairs in it. He sent me a picture as I had wished for pictures with a better solution than mine. While he explained his thought behind solving it, a …

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## [\[Market strategy\] GU-pair in a junction](https://forum.eternagame.org/t/market-strategy-gu-pair-in-a-junction/1142)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 4, 2012, 7:50pm UTC](https://forum.eternagame.org/t/market-strategy-gu-pair-in-a-junction/1142 "2012-02-04T19:50:00Z")

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If a GU is placed in a junction, the energy between it and the next basepair in the string shall be in a certain range. (if that is hook end of the neck or multiloop end of a neck or near any type of loop. 1-1 included –…

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## [\[Market strategy\] Max number of GC-pairs next to each other in strings 4 NT's long](https://forum.eternagame.org/t/market-strategy-max-number-of-gc-pairs-next-to-each-other-in-strings-4-nts-long/1140)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [February 4, 2012, 7:49pm UTC](https://forum.eternagame.org/t/market-strategy-max-number-of-gc-pairs-next-to-each-other-in-strings-4-nts-long/1140 "2012-02-04T19:49:00Z")

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I have noticed that the good designs don’t have more than max 2 GC-pairs in a row, in a string 4 nucleotides long. I would like a strategy specificly for strings 4 nucleotides long that says: Max. 2 GC-pairs next to eac…

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## [\[Market strategy\] Limited amounts of GU-pairs](https://forum.eternagame.org/t/market-strategy-limited-amounts-of-gu-pairs/1139)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 10\
**Last updated:** [January 31, 2012, 11:41pm UTC](https://forum.eternagame.org/t/market-strategy-limited-amounts-of-gu-pairs/1139 "2012-01-31T23:41:00Z")

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As the GU-pairs in designs continue to be a problem area for us, I would like a strategy that try only to limit the amount used, as to avoid a whole design gets messed up because of too many GU-pairs. I would like a str…

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## [\[Strategy Market\] Adjacent U's and C's](https://forum.eternagame.org/t/strategy-market-adjacent-us-and-cs/1115)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 2\
**Last updated:** [January 6, 2012, 2:39am UTC](https://forum.eternagame.org/t/strategy-market-adjacent-us-and-cs/1115 "2012-01-06T02:39:00Z")

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In stacks of any length, award points to an RNA anytime an AU pair is adjacent to a GC pair on the end or beginning of the stack if the Uracil is adjacent to the Cytosine. That is, for example, that the U of an AU bond w…

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## [\[Strategy Market\] Regarding Uracil](https://forum.eternagame.org/t/strategy-market-regarding-uracil/1113)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 1\
**Last updated:** [January 4, 2012, 9:57pm UTC](https://forum.eternagame.org/t/strategy-market-regarding-uracil/1113 "2012-01-04T21:57:00Z")

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This idea is based off of findings from the (RNA) series of puzzles. When Uracil was removed as an option for the random number generator and a NT sequence was generated using only the other 3 bases, the resulting shapes…

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## [\[Market strategy\] Rulesensitivity according to length of string](https://forum.eternagame.org/t/market-strategy-rulesensitivity-according-to-length-of-string/1112)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 1\
**Last updated:** [January 4, 2012, 9:56pm UTC](https://forum.eternagame.org/t/market-strategy-rulesensitivity-according-to-length-of-string/1112 "2012-01-04T21:56:00Z")

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I have been claiming this for a long time. Now I want to test it in strategy. Instead of combining it with my older strategies and potentially ruining them, I will make a new, to see if I can get proof in number for this…

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## [\[Strategy Market\] Xmas, cubs and illusions](https://forum.eternagame.org/t/strategy-market-xmas-cubs-and-illusions/1096)

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**Author:** [@Edward\_Lane](https://forum.eternagame.org/u/Edward_Lane)\
**Replies:** 14\
**Last updated:** [December 30, 2011, 11:50am UTC](https://forum.eternagame.org/t/strategy-market-xmas-cubs-and-illusions/1096 "2011-12-30T11:50:00Z")

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Apparently these are bad strategies - so please optimise them for the worst score possible (if they do actually come out negative as expected) strategy 1 - all base pairs are GC strategy 2 - all base pairs are AU stra…

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## [\[Strategy Market\] GC Vs GU in stacks](https://forum.eternagame.org/t/strategy-market-gc-vs-gu-in-stacks/1104)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 14\
**Last updated:** [December 26, 2011, 9:59pm UTC](https://forum.eternagame.org/t/strategy-market-gc-vs-gu-in-stacks/1104 "2011-12-26T21:59:00Z")

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Before I continue, my apologies if this has been mentioned before. So, while playing around in challenge mode, something caught my attention: The Uracil in GU pairs hates the Cytosine in GC pairs when they’re stacked cl…

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## [\[Strategy Market\] Zekrom Test](https://forum.eternagame.org/t/strategy-market-zekrom-test/1093)

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**Author:** [@Freywa](https://forum.eternagame.org/u/Freywa)\
**Replies:** 5\
**Last updated:** [December 24, 2011, 4:44am UTC](https://forum.eternagame.org/t/strategy-market-zekrom-test/1093 "2011-12-24T04:44:00Z")

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I’m not sure if this is even going to succeed in getting a correlation above 0, but here goes. Regarding stacks, at least half of the total number of pairs in the stack (rounded up) should be GCs, and the rest AUs. GUs …

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## [\[Strategy Market\] base pair percentages](https://forum.eternagame.org/t/strategy-market-base-pair-percentages/1092)

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**Author:** [@Edward\_Lane](https://forum.eternagame.org/u/Edward_Lane)\
**Replies:** 3\
**Last updated:** [December 24, 2011, 12:17am UTC](https://forum.eternagame.org/t/strategy-market-base-pair-percentages/1092 "2011-12-24T00:17:00Z")

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looking at this page http://getsatisfaction.com/eternagame… it appears that those results (over multiple tests) that had a 94% or better success rate had the following in common GC pairs less than 55%, AU pairs great…

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## [\[Strategy market\] Green paired with red](https://forum.eternagame.org/t/strategy-market-green-paired-with-red/1091)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 2\
**Last updated:** [December 24, 2011, 12:02am UTC](https://forum.eternagame.org/t/strategy-market-green-paired-with-red/1091 "2011-12-24T00:02:00Z")

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I would like a strategy that says, no green nucleotide allowed, if not paired up with a red nucleotide in a GC-pair. For each green nucleotide not paired up with red (alone – placed in outer loops, internal loops, multi…

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## [\[Strategy market\] Blue paired with yellow](https://forum.eternagame.org/t/strategy-market-blue-paired-with-yellow/1088)

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**Author:** [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)\
**Replies:** 3\
**Last updated:** [December 23, 2011, 11:53pm UTC](https://forum.eternagame.org/t/strategy-market-blue-paired-with-yellow/1088 "2011-12-23T23:53:00Z")

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I would like a strategy that says, no blue nucleotide allowed if not paired up with a yellow nucleotide in a AU-basepair. This strategy is in family with earlier strategies of mine, banning blue nucleotides in multiloop…

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## [\[Strategy Market\] Hard-Boiled](https://forum.eternagame.org/t/strategy-market-hard-boiled/1074)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 6\
**Last updated:** [December 16, 2011, 3:49am UTC](https://forum.eternagame.org/t/strategy-market-hard-boiled/1074 "2011-12-16T03:49:00Z")

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All credit to Quasispecies for pointing this out, and I’ll happily concede authorship of this strategy. Apparently, there is a correlation between successful lab candidates and a sharp melt curve- that is that, irregard…

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## [\[Strategy Market\]-Too many GU pairs makes design unstable](https://forum.eternagame.org/t/strategy-market-too-many-gu-pairs-makes-design-unstable/1072)

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**Author:** [@stevetclark](https://forum.eternagame.org/u/stevetclark)\
**Replies:** 1\
**Last updated:** [December 15, 2011, 7:48am UTC](https://forum.eternagame.org/t/strategy-market-too-many-gu-pairs-makes-design-unstable/1072 "2011-12-15T07:48:00Z")

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The presence of GU pairs could potentially make a design unstable. I predict that the percentage of GU pairs is inversely proportional to the synthesis score. If a design has 0% GU pairs then it scores 100. If it has 5% …

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## [\[Strategy Market\] The UA Swap](https://forum.eternagame.org/t/strategy-market-the-ua-swap/1071)

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**Author:** [@paramodic](https://forum.eternagame.org/u/paramodic)\
**Replies:** 1\
**Last updated:** [December 15, 2011, 7:46am UTC](https://forum.eternagame.org/t/strategy-market-the-ua-swap/1071 "2011-12-15T07:46:00Z")

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Take any RNA that has greater than 65% GC bonds. Select GC bonds that are not on the end of a string (in this case, a series of stacks, made individual by separation from other string by loops of any kind) and mutate the…

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