# Mg2+ mechanics may assist folding counter to expectations.

**URL:** https://forum.eternagame.org/t/mg2-mechanics-may-assist-folding-counter-to-expectations/1981
**Category:** General Science Discussion
**Created:** [November 9, 2013, 12:24am UTC](https://forum.eternagame.org/t/mg2-mechanics-may-assist-folding-counter-to-expectations/1981 "2013-11-09T00:24:00Z")
**Posts on this page:** 1
**Page:** 1

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### Author: ![eternacac](https://forum.eternagame.org/letter_avatar_proxy/v4/letter/e/977dab/32.png) [@eternacac](https://forum.eternagame.org/u/eternacac)
#### Post date: [November 9, 2013, 12:24am UTC](https://forum.eternagame.org/t/mg2-mechanics-may-assist-folding-counter-to-expectations/1981/1 "2013-11-09T00:24:00Z")

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In summary, this work clearly reveals that [Mg2]-mediated formation of an isolated TL-R tertiary interaction (i) is of an entropic origin, directly counter to traditional expectations for the role of Mg2 in tertiary RNA folding, and (ii) involves a sig-  
nificantly complex interplay between the ion atmosphere and the docked vs. undocked RNA structures along the folding pathway.

[http://www.pnas.org/content/early/201…](http://www.pnas.org/content/early/2012/01/30/1114859109.full.pdf)