# Please review the proposed puzzles for the initial OpenCRISPR round
**URL:** https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861
**Category:** Uncategorized
**Created:** [August 14, 2017, 11:25pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861 "2017-08-14T23:25:00Z")
**Posts on this page:** 20
**Page:** 5
### Author:  [@MasterStormer](https://forum.eternagame.org/u/MasterStormer)
#### Post date: [August 20, 2017, 2:43pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/113 "2017-08-20T14:43:00Z")
You also need to remove the cookies and the chache from what I understand.
---
### Author:  [@MasterStormer](https://forum.eternagame.org/u/MasterStormer)
#### Post date: [August 20, 2017, 2:50pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/115 "2017-08-20T14:50:00Z")
For me, after deleting the cookies (only read this after I deleted them), it appears in ON and doesn’t in OFF, as it should. However this 40k loop is a pretty weird quirk in the engine…
---
### Author:  [@whbob](https://forum.eternagame.org/u/whbob)
#### Post date: [August 20, 2017, 4:14pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/117 "2017-08-20T16:14:00Z")
I cleared the chache as well as the history, called up the puzzle, reset the puzzle, then pasted the solution and that did it.
Thanks so much.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 20, 2017, 8:51pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/118 "2017-08-20T20:51:00Z")
**TEP 1a - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGAGAUACCAGAUCAAUCUGGUAUAAGAAUUGACAUGAGGAUCACCCAUGUGAAUAAAGACAGAAUAAGUGAUCCCUUGGCAGCUCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 20, 2017, 9:53pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/119 "2017-08-20T21:53:00Z")
**TEP 1a - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACAGAUACCAGACAUUCUGGUAUAGAUCUCAGAUGUCAUUGACAUCUGAGAUCUACAUGAGGAUCACCCAUGUCCCUUGGCAGCUGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 20, 2017, 10:34pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/120 "2017-08-20T22:34:00Z")
**TEP 1b - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGACCCUUGGCAGCAUGAAACAUGAGGAUCACCCAUGUAGAUGAGACAUUUGUCUCAUCUUCGUUUUGAACCUCAUGAUACCAGUCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 20, 2017, 11:12pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/121 "2017-08-20T23:12:00Z")
**TEP 1b - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACACCCUUGGCAGCACAUUAAAGAUCUCUCGAGUCAUUUGACUCGAGAGAUCAAAUUACAUGAGGAUCACCCAUGUGAUACCAGUGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 20, 2017, 11:52pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/122 "2017-08-20T23:52:00Z")
**TEP**** 2 - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACAGAACAUGAGGAUCACCCAUGUAAAAUGAUACCAGCAGAUUUCUGCCCUUGGCAGCAUGGGUAGAGCGAUUUCGCUCAAAACUGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 12:44am UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/123 "2017-08-21T00:44:00Z")
**TEP**** 2 - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACAGUAUAUGAGUGAACACAUCGGAAGGUGAUACCAGCUGAUUUCAGCCCUUGGCAGCACAUGAGGAUCACCCAUGUAAUAUACUGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Ugly solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 1:10am UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/124 "2017-08-21T01:10:00Z")
**TEP 3 - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACAGAAAAUGAUACCAGAGCAUUUGCUCCCUUGGCAGCAUGUGUAUAAUUAUACACAUGAGGAUCACCCAUGUAAGAAAUAAUCUGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 1:48am UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/125 "2017-08-21T01:48:00Z")
**TEP**** 3 - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACGGAUGUGGAUACCAGCUCAUUUGAGCCCUUGGCAGCUACAUGAGGAUCACCCAUGUAAGAUCUCUCAUUUGAGAGAUCAAACCGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 2:33am UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/126 "2017-08-21T02:33:00Z")
**TEP**** 4 - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGAGCAAUAAAUAAUAAACAUGAGGAUCACCCAUGUGAUAAAAUCACAUGAUACCAGCUCAUUUGAGCCCUUGGCAGCAUAAGCUCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 2:56am UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/127 "2017-08-21T02:56:00Z")
**TEP 4 - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGACAUAAUUGCUCGCAUUUGUGAGCACACACAUGAGGAUCACCCAUGUGAUACCAGCUCAUUUGAGCCCUUGGCAGCACAUUGUCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 3:06pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/128 "2017-08-21T15:06:00Z")
**Tetracycline - Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACUAAAACAUACCUUAUGUAAAUAAAACAUGAGGAUCACCCAUGUAAAUAAAUAUAUAGGGAGAGGUGAAGAAUACGACCACCUAGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
This solution was not a mod but turned out to be very similar to Eli’s, both work in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 3:32pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/129 "2017-08-21T15:32:00Z")
**Tetracycline - Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACUAAAACAUACCACAUGAGGAUCACCCAUGUAAAAGAGCUCAUUUGAGCUCAAAGUGUGGAGAGGUGAAGAAUACGACCACCUAGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 4:19pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/130 "2017-08-21T16:19:00Z")
**Tetracycline**** inv ****- Same State**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGGAGAGGUGAAGAAUACGACCACCUAGGAAUCUCAUGUAAAACAUGAGGAUCACCCAUGUAAAUUGAAUGAUCCUAAAACAUACCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 4:43pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/131 "2017-08-21T16:43:00Z")
**Tetracycline**** inv ****- Exclusion**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAGGAGAGGUGAAGAAUACGACCACCUAGUACAUGAGGAUCACCCAUGUAAAACAUGUAAAUUAAAUAUGAUGUACUAAAACAUACCUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@AndrewKae](https://forum.eternagame.org/u/AndrewKae)
#### Post date: [August 21, 2017, 5:30pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/132 "2017-08-21T17:30:00Z")
**Control ON**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAUAAUAAUAGCUAUAUAGAAAUAUAUAGGAUAUAACAUGAGGAUCACCCAUGUUAUAUCGAAUAUAGAAAUAUAUUCCUAUUAUUAUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
**Control OFF**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACUCUCUGACCAAUCUCGAAAGAGAUUGUCAUGUACAUGAGGGAAACCCAUGUACAUGAGGAUCACCCAUGUGAUCCGUCAGAGAGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
**Control ON (freestyle)**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUAUAACUAAAGCUCAGAAGAAAUUCUGAGGUUAGAACAUGAGGAUCACCCAUGUUCUAACGACUAGAGAAAUCUAGUCCUUUAGUUAUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
**Control OFF (freestyle)**
GACGCAUAAAGAUGAGACGCGUUUGAGAGCUACUGUCUGACCAAUCUCGAAAGAGAUUGUCAUGUACAUGAAAGAAACCCAUGUACAUGAGGAUCACCCAUGUGAUCCGUCAGACAGUAGCAAGUUCAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUU
Solution works in all 3 models.
---
### Author:  [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)
#### Post date: [August 22, 2017, 12:59pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/133 "2017-08-22T12:59:00Z")
Also for those who are not doing puzzles at the moment and may not have noticed, there is a [CRISPR training series](https://www.eternagame.org/web/playerpuzzles/?search=crispr&sort=date) up under puzzles. The aim is teaching some of the skills for doing good for the coming CRISPR lab. With focus on using what we have already learned from past labs + transfering some of our past winning designs to the CRISPR lab as for making potential winners much faster.
---
### Author:  [@Omei](https://forum.eternagame.org/u/Omei)
#### Post date: [August 22, 2017, 7:11pm UTC](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861/134 "2017-08-22T19:11:00Z")
First of all, I want to thank everyone who has helped us test these puzzles. The feedback resulted in numerous very significant improvements and fixes. Special kudos are due to Andrew, who submitted solutions satisfying all three folding engines, for all the final puzzle versions!
Barring any last minute surprises, the puzzles are now finalized. If you are so inclined, you can start working on them now; you just have to keep a copy of your solutions and submit them when the round officially starts. (When? Soon, but exact date still TBD.) But this pause brings up another thought.
Once a lab opens, we are generally too busy working on generating lots of solutions to take the time to discuss our ideas for how to best solve them. I think we might get a jump on new puzzles if we shared ideas on how we think we can best apply lessons from the past. Eli has jump-started this with his player puzzle tutorial series. Are there other thoughts? @Andrew, you’ve obviously gotten very good at generating high quality solutions. Can you share anything about your process?
[Previous page](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861.md?page=4)
[Next page](https://forum.eternagame.org/t/please-review-the-proposed-puzzles-for-the-initial-opencrispr-round/2861.md?page=6)