# \[Strategy Market\] \[Switch\] Entropy in MS2/microRNA designs

**URL:** https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347
**Category:** Strategy Market - Switches
**Created:** [June 16, 2015, 11:08pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347 "2015-06-16T23:08:00Z")
**Posts on this page:** 5
**Page:** 1

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### Author: ![Eli\_Fisker](https://forum.eternagame.org/user_avatar/forum.eternagame.org/eli_fisker/32/4453_2.png) [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)
#### Post date: [June 16, 2015, 11:08pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347/1 "2015-06-16T23:08:00Z")

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**Strategy**

Give -1 for designs having lower than 0.6 in entropy and penalize exponentially  
Give +1 for designs having above 0.6-0.8 in entropy  
Give +3 to designs having between 0.9-1.5 in entropy  
Give +1 to designs that have above 1.6 and above and start penalize exponentially

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### Author: ![vineetkosaraju](https://forum.eternagame.org/letter_avatar_proxy/v4/letter/v/4491bb/32.png) [@vineetkosaraju](https://forum.eternagame.org/u/vineetkosaraju)
#### Post date: [June 29, 2015, 7:55pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347/2 "2015-06-29T19:55:00Z")

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Dear Eli Fisker,  
&nbsp;  
Your strategy has been added to our implementation queue and we should have it completed within the next two to three weeks. You can check the status of the implementation [here](https://github.com/vineetsk1/Switch-Strategies/issues/24).

We will also be uploading the code used to write your strategy on this [page](https://github.com/vineetsk1/Switch-Strategies) if you are interested in reading it later.

After implementing your idea, we will post the direct link to the code here. Then, we will then optimize the parameters, and test it. At that point, we will tell you the correlation of how good your strategy was and what the new optimized parameters are.

Thanks for sharing your idea!

Vineet Kosaraju  
The EteRNA Team

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### Author: ![vineetkosaraju](https://forum.eternagame.org/letter_avatar_proxy/v4/letter/v/4491bb/32.png) [@vineetkosaraju](https://forum.eternagame.org/u/vineetkosaraju)
#### Post date: [July 5, 2015, 5:01pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347/3 "2015-07-05T17:01:00Z")

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Hi Eli,

Just want to confirm that this is not a typo:

_Give +1 to designs that have above 1.6 and above and start penalize exponentially_

If the entropy is at around 1.6 I’ll give +1, but after that the reward drops off exponentially until it becomes a penalty?

Thanks,  
Vineet

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### Author: ![Eli\_Fisker](https://forum.eternagame.org/user_avatar/forum.eternagame.org/eli_fisker/32/4453_2.png) [@Eli\_Fisker](https://forum.eternagame.org/u/Eli_Fisker)
#### Post date: [July 5, 2015, 5:06pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347/4 "2015-07-05T17:06:00Z")

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_If the entropy is at around 1.6 I’ll give +1, but after that the reward drops off exponentially until it becomes a penalty?_

Yup, you got it. I think 1.6 is not a crime, but still rewardable, I just think as it goes further up it does not benefit the design, so I want to penalize it, but stating gradually and going to a more extreme, the higher entropy becomes.

I wasn’t sure how to jump from +1 reward to drop reward then go on to penalizing increasingly.

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### Author: ![vineetkosaraju](https://forum.eternagame.org/letter_avatar_proxy/v4/letter/v/4491bb/32.png) [@vineetkosaraju](https://forum.eternagame.org/u/vineetkosaraju)
#### Post date: [July 5, 2015, 5:24pm UTC](https://forum.eternagame.org/t/strategy-market-switch-entropy-in-ms2-microrna-designs/2347/5 "2015-07-05T17:24:00Z")

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Dear Eli Fisker,

I am pleased to announce that a preliminary version of your strategy has been implemented with 26 lines of code. The code might slightly change in the future to remove bugs, but you can check the current version [here](https://github.com/vineetsk1/Switch-Strategies/blob/master/eli_fisker_entropy_in_MS2_microRNA_designs.py). We will soon work on optimizing your parameters and testing the strategy.

Thank you again for sharing your switch strategy!

Vineet Kosaraju  
The EteRNA Team
