Dynamic and Unconstrained Lab Structures
This is something I could see more in the “future” of the player projects.
As of right now, players are limited as to what their project can be. More specifically, they are limited to a specific target structure, and for those players who are thinking “big” this will definitely limit their hopes and dreams. So, let’s go over a few proposals that could help this idea out.
Dynamic Lab structures
This is definitely something that could be interesting for players to get a hold of (as it is being developed for the Theophylline Ribozyme switch puzzles). Essentially, players could define a specific “structure” and players could fill in the rest of the 63 bases required for the design however they wish. This could allow a project that says “Insert this 2-2 Loop with an isolated base pair on a multiloop.” Instead of 10 separate projects, one with a 2-2 loop of a multiloop, one with a 2-2 loop off of the open loop, one with a 2-2 loop off of a hairpin loop, and so on and so forth. If this could prove too difficult to implement, then, the next idea may be better.
Multiple Defined Target Structures in a Single Project
So, let’s say a player like myself comes up with the project “A-U closing base pairs.” Ultimately, my goal with this project would be to define the upper limit for the chemical detection of A-U pairs when used as closing base pairs of a loop. However, there are hundreds of different circumstances I could ultimately test with this, but the number of different lab projects that would be needed to test these all would be enormous, taking up valuable space if they were all running at the same time. So, instead, when I propose a project, I will have the 30 different target structures already a part of the project itself, and the lab admins (or players who participate in the lab?) will ultimately choose which targets get synthesis slots that round, when a target is closed, etc. If this is too difficult to do, perhaps this next idea could work.
Lab Project Grouping and Categorization
So, one thing I noticed while going through the “past labs” is that there are now quite a large number. Maybe we can “group” all these individual labs into packets. For example, all the lab targets for the Player Projects could be categorized into a single project named “EteRNA Cloud: Player Projects - R69”. Once we click on the project, a new page opens that contains all of the lab targets, or,it could be broken down once again, with each player who submitted a project getting their own “folder” that contains all the labs they proposed. Ultimately, this could make it easier for players if all projects were categorized in a form like this, instead of going through everything trying to find a specific lab. This also gives players the chance to propose new labs that can be voted on for activity, which can be placed into the same project folder, making it easier to find specific data.
Unconstrained Lab targets
If I proposed a project that asked players to go to a database, submit and cite a sequence based on natural RNA sequences, they would most likely break any structural constraints that are there. However, if players were able to submit a sequence and structure, similar to how the puzzlemaker works, this would allow them to do so. This is somewhat like the dynamic lab structures idea, however, with this, none of the target structure would be predefined, it would just be free designing of RNA based on whatever the lab admin/proposer asks of the players for their project.