Here is a picture of what would be given to players in the lab. This is a solution to the “pincers” switch from the challenges where the 2nd state has 0CG.
My hypothesis is that the state with the more CG will be the one that is predominant in the ensemble - State 1 with 2 CG in it.
The 2nd state is not stable without a molecule but it is my understanding that it will appear some of the time even without a molecule.
Players will be limited in the number of mutations (say 10-20) that they can make to this lab such that an AU pair could be made into a CG pair with 2 mutations.
For example: http://eterna.cmu.edu/sites/default/f…
with 4 mutations a player could design this sequence giving the second state 2CG and the first state 3CG. the ratio of the CG count in the states is now 3:2 instead of 2:0.
While state 1 is still stable and state 2 is not, my hypothesis is that state 2 will be more prevalent than it was before. Should state 2 be given more CG than state 1 my hypothesis would be that it would become more prevalent in the ensemble.
(This example ignores the collapsing of the aptamer that players can mutate away if they wish and of course any switch puzzle/lab could be substituted for “pincers” with the same idea.)