i ve got this error
while regular playing (not with any copy-paste seq)
-only when trying to switch natural mode
SEQ: GGGAACGACUCGAGUAGAGUCGAAAAGCGCGCAGGGCCGGGCGCGCGGGUACCACGCGCGCCAGUCAGGCGCGACUGACUGAAAAAAAUGGUACCAUUAAUUCCGGCCCAAAUUAAAAAAAAAUUCGAAAAAAAAAAAGAAACAACAACAACAAC
screenshots:
That’s an error in the original NuPACK code. NUPACK fails to fold certain sequences for some reason. We won’t be able to fix this since it’s not a problem in the Eterna system, it’s something flawed in the NuPACK algorithm we are borrowing.
Thank you for reporting the error message! Now everyone else will know as well. I’ve only gotten the error message once myself, while solving a player pseudoknot puzzle.
(Late) following up on this: It appears to be due to NuPACK running out of memory. NuPACK’s pseudoknot folding (in particular) is highly inefficient, and gets progressively worse as the length increases. At ~180 bases, for example, NuPACK can use 3-4GB (!) of RAM (in addition to taking a pretty long time to fold). This can particularly be an issue on mobile devices for example (in many cases the PK90 would crash immediately), if have many browser tabs or other programs open (particularly on lower-memory devices like Chromebooks), etc. Unfortunately this isn’t something we have control over (or can even reliably detect), so I’ll be marking this issue as “wontfix”. We’ve recently introduced a new engine that is significantly more efficient (and from what we’ve seen, more accurate!) which will be available going forward.
