Intro
As I were looking repeat bases in top scoring switch designs, I noticed that there seemed to be a relation between amount of single bases in relation to each other. There generally were more single A’s than single U’s, more U’s than single G’s and C’s. And there tended to be more G’s than C’s, although not always. (When I mention single here, I do not look at weather they are paired or not, I’m only looking at that they are not repeat bases.)
There were more single A’s and U’s than single C’s and G’s together. No surprise about the relation there, since this reveals relation of Watson Crick base pairing. Also it seems that there can’t be too big different in amounts of the different bases.
Strategy
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Reward when there are more single A’s and U’s when summed, than single C’s and G’s summed
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Reward when there are more A’s than U’s, more U’s than G’s and more G’s than C’s.
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Reward when the relationship between bases are as following: There can’t be more than 8% difference between any of the single bases in amount.
Along the lines of my earlier repeat base strategy, there can’t be more single bases than 60-70 % for turnoff labs and 50-60% for turn on labs.