Just a few quick notes in reference to last week’s chat between the developers and the players.
Tentatively, we are planning on having chats between developers and players every other week. This means our next meeting will likely be on Wednesday, November 14, at 3:00 pm PST. We will confirm that soon - and looking forward to it!
As mentioned, the EteRNA team is planning on revising the scoring function for switch puzzles. While the new rules are not finalized yet, we feel that our current scoring scheme is a bit too harsh - we think that the new scoring system will be more fair AND generally result in higher scores for designs that correctly form the FMN aptamer. Look for an update on that within a week or so - no word yet on whether or not old puzzles will be re-scored.
We also mentioned that we are are pursuing other ligand-binding aptamers to drive RNA switches. We will start by focusing on the molecule theophylline - just like with FMN, there is a tight-binding aptamer for theophylline that we can plug into lots of different structures. For now, and the near future, we will mostly still work on FMN in the lab; theophylline puzzles will be restricted to the challenge section. One day, they will become lab puzzles, though!